Engineered Salt-insensitive α-Defensins with End-to-end Circularized Structures
نویسندگان
چکیده
منابع مشابه
Engineered salt-insensitive alpha-defensins with end-to-end circularized structures.
We designed a retro-isomer and seven circularized "beta-tile" peptide analogs of a typical rabbit alpha-defensin, NP-1. The analogs retained defensin-like architecture after the characteristic end-to-end, Cys(3,31) (C I:C VI), alpha-defensin disulfide bond was replaced by a backbone peptide bond. The retro-isomer of NP-1 was as active as the parent compound, suggesting that overall topology and...
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متن کاملcomparison of nerve repair with end to end, end to side with window and end to side without window methods in lower extremity of rat
abstract background : although, different studies on end-to-side nerve repair, results are controversial. the importance of this method in case is unavailability of proximal nerve. in this method, donor nerves also remain intact and without injury. in compare to other classic procedures, end-to-side repair is not much time consuming and needs less dissection. overall, the previous studies in ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.6.3943